Podocyte Mitosis - A Catastrophe
نویسندگان
چکیده
منابع مشابه
Podocyte Mitosis – A Catastrophe
Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm. Maintaining these sophisticated structural elements requires an...
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Podocyte injury and depletion are essential events involved in the pathogenesis of diabetic nephropathy (DN). As a terminally differentiated cell, podocyte is restricted in 'post-mitosis' state and unable to regenerate. Re-entering mitotic phase will cause podocyte disastrous death which is defined as mitotic catastrophe (MC). Murine double minute 2 (MDM2), a cell cycle regulator, is widely exp...
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Two parallel and concordant activities characterize cell cycle progression. One is associated with preparation for and execution of DNA replication followed by mitosis (" cell cycle "). Cyclins are the motors of the cell cycle, as they activate the respective CDKs and thereby drive the cell through the sequential phases of the cycle. Their antagonists are CKIs, which inhibit the CDKs stalling t...
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In recent years catastrophe reinsurers' use of catastrophe models has been increasing until currently virtually all of the catastrophe reinsurers in the world use a catastrophe model to aid them in their pricing and portfolio management decisions. This paper explicitly models various types of reinstatement provisions, including reinstatements that are limited by the number of occurrences and by...
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ژورنال
عنوان ژورنال: Current Molecular Medicine
سال: 2013
ISSN: 1566-5240
DOI: 10.2174/15665240113138880020